Intravenous Vitamin C as an Adjunct in Cancer care

It is important to note, that Dr Stewart does not treat cancer, however he does treat patients who have cancer and who are also receiving traditional cancer therapies, such as chemotherapy, immunotherapy and radiation.

Although the literature and clinical studies clearly show IVC has a good safety profile and potentially important anti-tumor activity as an adjunctive therapy in the treatment of cancer, it is not considered a “stand alone” therapy. 

 

It is one component of multi-faceted comprehensive care that should include other treatments and lifestyle changes that support wellness.  IVC can be used with traditional cancer treatments such as surgery, chemotherapy, and radiation.

Because of IVC's positive effect on cancer symptoms, treatment side effects, enhanced quality of life, and disease outcome, intravenous vitamin C should be considered a valuable adjunctive medical therapy for cancer. 

 

Administered via IV in high doses (25,000 mg and up), vitamin C behaves like a non-toxic chemotherapeutic agent and can even be given in conjunction with conventional cancer treatments.

IV vitamin C, when administered by a trained, experienced physician, is safe and generally well-tolerated, even at doses as high as 100,000 mg (100 grams) per day.

Overview

IV Vitamin C has been used in the supportive care for patients with cancer for many years and has been proven by many studies and patient experiences, to be very beneficial.

One of the main reasons its used by patients, is for improved Quality of Life. This can be a major factor for many patients when undergoing standard medical care, and also patients use it for a variety of other health conditions also.

It is now known, that Vitamin C levels are very often depleted in patients when undergoing chemotherapy in particular, which can also result in having an impact on food and nutrient absorption abilities for many, thereby limiting their ability to maintain good Vitamin C blood plasma levels in their bodies.

This is why IV Vitamin C infusions can be so beneficial to patients as it bypasses any gastrointestinal issues and can be absorbed quickly throughout the body where its needed.

In times of illness, injury or even stress, our metabolic demand for Vitamin C rises, and can quickly deplete our body's reserves and if we also have poor nutrition or no supplementation, it can lead to even more health issues.

Vitamin C is an essential nutrient that is needed at certain levels to maintain good health and in even higher amounts during times of illness.

 

Now an ever increasing number of new studies have now been able to show more precisely why IVC is so beneficial, to a wide variety of health conditions and especially to patients with cancer.

Explain Hypovitaminosis

Pubmed-logo.png

You can search PubMed for additional peer reviewed studies for any subject mentioned on this page.

Pubmed- "Vitamin C"

- 63,711 studies *

This is on Pubmed alone.

There are many other Journals  and Publications going back to the 1930's..

*as of December 2019 - more may be added since

Use the expandable drop down tabs below for more information

Additional Sources

Vitamin C is also known as "Ascorbic acid" and L-ascorbic acid, is a very highly studied element in medical literature.It is even now also referred to as PAA  - Pharmacological Ascorbate Acid

In the last couple of years there has been a very significant renewed level of interest in IVC (possibly caused by the new Sepsis studies) and a also lot of other new studies have since been published, which are now showing even more positive and new information, especially in relation to the cofactor functions of Vitamin C.

IV Vitamin C for Patients with Cancer

IVC improves Quality of Life


Several recent studies have indicated that intravenous (IV) vitamin C alleviates a number of cancer- and chemotherapy-related symptoms, such as fatigue, insomnia, loss of appetite, nausea, and pain. Improvements in physical, role, cognitive, emotional, and social functioning, as well as an improvement in overall health, were also observed. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199254/ https://www.ncbi.nlm.nih.gov/pubmed/22021693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693571/




IVC can work in tandem with Traditional Therapies


Ascorbic acid (Vitamin C) was found to be beneficial for the treatment of cancer in studies, only when administered intravenously and in high and frequent doses. When given in combination with standard therapy and in the absence of renal failure, the overall reported adverse events were not greater than therapy-induced complaints. There was no increase in toxicity; yet, the results were promising and decreased levels of the inflammatory marker CRP were shown, as well as an improvement in the efficacy of chemotherapy and thus, an increase in survival times. Moreover, patients reported an improvement in quality of life and increased energy. Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164730/ Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma. https://www.ncbi.nlm.nih.gov/pubmed/29547353




Vitamin C is a vital element in all treatment approaches


Humans have an absolute requirement for vitamin C (ascorbate) as part of their diet, and deficiency due to inadequate intake is associated with a plethora of symptoms, reflecting the diverse functions attributed to the vitamin. Additionally, in the last 15 years, the many cofactor functions of ascorbate have come to the fore. see >> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195639/ Vitamin C is also known as ascorbic acid. Vitamin C is a water-soluble vitamin, one that cannot be stored by the body except in insignificant amounts. It must be replenished frequently. Vitamin C, a powerful antioxidant, is needed and used for a wide variety of functions within the body. It is necessary for the growth, development and repair of all body tissues. It's involved in many body functions, including formation of collagen, absorption of iron, the immune system, wound healing, and the maintenance of cartilage, bones, and teeth. See additional functions here > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/ At times of injury, stress, infection, illness or disease, our metabolic demand for Vitamin C is elevated, and is required in larger amounts as it is used up to help the body repair and heal. Most of the plant and animal species have the ability to synthesize vitamin C from glucose and galactose through uronic acid pathway but man and other primates cannot do so because of deficiency of enzyme gulonolactone oxidase [EC 1.1.3.8] required for it’s biosynthesis. Deficiency of this enzyme is a result of a mutation which occurred approximately 40 million years ago [ ref link]. __________________________________ Although vitamin C is a potent antioxidant protecting the body against endogenous and exogenous oxidative challenges, it is likely that its action as a cofactor for numerous biosynthetic and gene regulatory enzymes plays a key role in its immune-modulating effects. Vitamin C stimulates neutrophil migration to the site of infection, enhances phagocytosis and oxidant generation, and microbial killing. At the same time, it protects host tissue from excessive damage by enhancing neutrophil apoptosis and clearance by macrophages, and decreasing neutrophil necrosis and NETosis. Thus, it is apparent that vitamin C is necessary for the immune system to mount and sustain an adequate response against pathogens, whilst avoiding excessive damage to the host. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/




IVC can augment some chemotherapy drugs


Clinical trials indicate that IVC does not adversely interfere with chemotherapy and pre-clinical studies indicate that it may in fact act synergistically in combination with different chemotherapeutic agents. Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115501/ see also>> https://www.medicalnewstoday.com/articles/272408.php




IVC can augment Radio Therapy


There is new research (early 2019) that shows when IVC is used alongside radiotherapy, for some types of cancer, IVC can enhance the radiosensitivity of tumors using this treatment. https://www.ncbi.nlm.nih.gov/pubmed/?term=PMID%3A+30376411




What are the relevant mechanisms of action of IVC?


A number of plausible anti-cancer mechanisms have been proposed, such as indirect generation of hydrogen peroxide, enzyme cofactor activities (e.g., collagen synthesis, HIF hypoxic response regulation, TET and JHDM epigenetic regulation), as well as antioxidant and anti-inflammatory functions. Different cancers likely respond differently to IVC therapy depending upon their underlying mechanisms. Thus, future work should focus on tailoring IVC regimens to specific cancers or cancer subtypes, e.g., hematological cancers that are driven specifically by TET mutations may respond more readily to IVC therapy. Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115501/




IVC reduces Fatigue, one of the most common issues for patients with cancer


Fatigue is one of the most common and debilitating symptoms reported by cancer patients and can affect QOL more than pain. Several recent studies have indicated that intravenous (IV) vitamin C alleviates a number of cancer- and chemotherapy-related symptoms, such as fatigue, insomnia, loss of appetite, nausea, and pain. Improvements in physical, role, cognitive, emotional, and social functioning, as well as an improvement in overall health, were also observed. The Effect of Intravenous Vitamin C on Cancer- and Chemotherapy-Related Fatigue and Quality of Life https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199254/




IVC helps with Pain, that can be experienced by some patients with cancer.


The prevalence of hypovitaminosis C and vitamin C deficiency is high in various patient groups, such as surgical/trauma, infectious diseases and cancer patients. A number of recent clinical studies have shown that vitamin C administration to patients with chronic regional pain syndrome decreases their symptoms. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391567/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142887/




IVC has been shown to slow the progression of some cancers


Apart from its biochemical functions that are met by healthy nutritional levels, recent pharmacokinetic data indicate that intravenous administration of ascorbate bypasses the tight control of the gut and renal excretion; thus, intravenous administration of ascorbate will produce highly elevated plasma levels; this ascorbate will autoxidize resulting in a high flux of extracellular H2O2. This H2O2 will readily diffuse into cells challenging the intracellular peroxide-removal system, initiating oxidative cascades. These high fluxes of H2O2 appear to have little effect on normal cells but can be detrimental to certain tumor cells. Knowledge and understanding of these mechanisms brings a rationale to the use of high-dose ascorbate to treat disease and thereby is reviving interest in the use of i.v. ascorbate in cancer treatment. Ascorbic acid: Chemistry, biology and the treatment of cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608474/ ______________________________________ Anti-Angiogenesis "Our studies have demonstrated that high concentrations of AA (ascorbic acid - vitamin c) affect the initial phase of cell migration and tube vessel formation and thereby can inhibit angiogenesis" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562367/




IVC has been shown as an excellent Palliative treatment


"Intravenous vitamin C application seems to reduce pain in patients in comparison to other patients who did not receive it. Patient performance status and survival rate were increased using vitamin C." https://www.ncbi.nlm.nih.gov/pubmed/26168394 -------------------------- "Improvements in physical, emotional, cognitive, and social functioning were also observed, as well as an enhancement of overall QOL. With respect to the multidimensional aspects of fatigue, a decrease in physical, emotional, and mental fatigue, resulting in a 50% decrease in total fatigue, was observed following vitamin C administration." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199254/#S4title -------------------------- In terminal cancer patients, the quality of life is as important as cure. Although there is still controversy regarding anticancer effects of vitamin C, t he use of vitamin C is considered a safe and effective therapy to improve the quality of life of terminal cancer patients. https://www.ncbi.nlm.nih.gov/pubmed/17297243/




IVC reduces Inflammation in patients with cancer.


Inflammation plays a key role in tumour development, affecting tumour proliferation, angiogenesis, metastasis, and resistance to therapy. Key features of cancer-related inflammation (CRI) include leukocyte infiltration, cytokine build-up, tissue remodelling, and angiogenesis. The high dose intravenous ascorbic acid (Vitamin C) therapy affects C-reactive protein levels and pro-inflammation cytokines in cancer patients. In our study, we found that modulation of inflammation by IVC correlated with decreases in tumor marker levels. Effect of high-dose intravenous vitamin C on inflammation in cancer patients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480897/ Also see> "..in the last 15 years, the many cofactor functions of ascorbate have come to the fore"
Vitamin C and immune cell function in inflammation and cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195639/




IVC aids healing after surgery


Barrier Integrity and Wound Healing The skin has numerous essential functions, the primary of which is to act as a barrier against external insults, including pathogens. The epidermal layer is highly cellular, comprising primarily keratinocytes, whilst the dermal layer comprises fibroblasts which secrete collagen fibers, the major component of the dermis [ ref]. Skin contains millimolar concentrations of vitamin C, with higher levels found in the epidermis than the dermis. Vitamin C is actively accumulated into the epidermal and dermal cells via the two sodium-dependent vitamin C transporter (SVCT) isoforms 1 and 2, suggesting that the vitamin has crucial functions within the skin. Clues to the role of vitamin C in the skin come from the symptoms of the vitamin C deficiency disease scurvy, which is characterized by bleeding gums, bruising, and impaired wound healing. These symptoms are thought to be a result of the role of vitamin C as a co-factor for the prolyl and lysyl hydroxylase enzymes that stabilize the tertiary structure of collagen. Further research has shown that vitamin C can also increase collagen gene expression in fibroblasts. Full study links in section 2 here >> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/




IVC boosts the Immune System


More than half a century of research has shown Vitamin C to be a crucial player in various aspects of the immune system, particularly immune cell function. Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic and gene regulatory enzymes. Vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system. Vitamin C supports epithelial barrier function against pathogens and promotes the oxidant scavenging activity of the skin, thereby potentially protecting against environmental oxidative stress. Vitamin C accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of reactive oxygen species, and ultimately microbial killing. It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage. The role of vitamin C in lymphocytes is less clear, but it has been shown to enhance differentiation and proliferation of B- and T-cells, likely due to its gene regulating effects. Vitamin C deficiency results in impaired immunity and higher susceptibility to infections. In turn, infections significantly impact on vitamin C levels due to enhanced inflammation and metabolic requirements. Furthermore, supplementation with vitamin C appears to be able to both prevent and treat respiratory and systemic infections. Prophylactic prevention of infection requires dietary vitamin C intakes that provide at least adequate, if not saturating plasma levels (i.e., 100–200 mg/day), which optimize cell and tissue levels. In contrast, treatment of established infections requires significantly higher (gram) doses of the vitamin to compensate for the increased inflammatory response and metabolic demand. Vitamin C and Immune Function https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/ Also see> "..in the last 15 years, the many cofactor functions of ascorbate have come to the fore"
Vitamin C and immune cell function in inflammation and cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195639/




Is IVC a vitamin or a drug?


IVC shifts ascorbate function from a simple anti-scurvy vitamin to a surprisingly beneficial pro-oxidant with powerful pharmaceutical actions. Pharmaceutical IVC doses have shown significant anticancer effects in studies. This well studied effect has been described as the “selective cytotoxicity effect of high dose ascorbate on tumor cells.” Numerous research institutions have replicated this effect over the last several decades. Only recently has research on sepsis brought this effect to the attention of conventional medicine. ----------------------- Recently IVC is also being referred to as Pharmacological Ascorbate Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma. https://www.ncbi.nlm.nih.gov/pubmed/29547353




Why is IV Vitamin C considered to be 'controversial'?


..........under construction.......





Frequently asked questions

IVC improves Quality of Life


Several recent studies have indicated that intravenous (IV) vitamin C alleviates a number of cancer- and chemotherapy-related symptoms, such as fatigue, insomnia, loss of appetite, nausea, and pain. Improvements in physical, role, cognitive, emotional, and social functioning, as well as an improvement in overall health, were also observed. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199254/ https://www.ncbi.nlm.nih.gov/pubmed/22021693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693571/




IVC can work in tandem with Traditional Therapies


Ascorbic acid (Vitamin C) was found to be beneficial for the treatment of cancer in studies, only when administered intravenously and in high and frequent doses. When given in combination with standard therapy and in the absence of renal failure, the overall reported adverse events were not greater than therapy-induced complaints. There was no increase in toxicity; yet, the results were promising and decreased levels of the inflammatory marker CRP were shown, as well as an improvement in the efficacy of chemotherapy and thus, an increase in survival times. Moreover, patients reported an improvement in quality of life and increased energy. Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164730/ Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma. https://www.ncbi.nlm.nih.gov/pubmed/29547353




Vitamin C is a vital element in all treatment approaches


Humans have an absolute requirement for vitamin C (ascorbate) as part of their diet, and deficiency due to inadequate intake is associated with a plethora of symptoms, reflecting the diverse functions attributed to the vitamin. Additionally, in the last 15 years, the many cofactor functions of ascorbate have come to the fore. see >> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195639/ Vitamin C is also known as ascorbic acid. Vitamin C is a water-soluble vitamin, one that cannot be stored by the body except in insignificant amounts. It must be replenished frequently. Vitamin C, a powerful antioxidant, is needed and used for a wide variety of functions within the body. It is necessary for the growth, development and repair of all body tissues. It's involved in many body functions, including formation of collagen, absorption of iron, the immune system, wound healing, and the maintenance of cartilage, bones, and teeth. See additional functions here > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/ At times of injury, stress, infection, illness or disease, our metabolic demand for Vitamin C is elevated, and is required in larger amounts as it is used up to help the body repair and heal. Most of the plant and animal species have the ability to synthesize vitamin C from glucose and galactose through uronic acid pathway but man and other primates cannot do so because of deficiency of enzyme gulonolactone oxidase [EC 1.1.3.8] required for it’s biosynthesis. Deficiency of this enzyme is a result of a mutation which occurred approximately 40 million years ago [ ref link]. __________________________________ Although vitamin C is a potent antioxidant protecting the body against endogenous and exogenous oxidative challenges, it is likely that its action as a cofactor for numerous biosynthetic and gene regulatory enzymes plays a key role in its immune-modulating effects. Vitamin C stimulates neutrophil migration to the site of infection, enhances phagocytosis and oxidant generation, and microbial killing. At the same time, it protects host tissue from excessive damage by enhancing neutrophil apoptosis and clearance by macrophages, and decreasing neutrophil necrosis and NETosis. Thus, it is apparent that vitamin C is necessary for the immune system to mount and sustain an adequate response against pathogens, whilst avoiding excessive damage to the host. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/




IVC can augment some chemotherapy drugs


Clinical trials indicate that IVC does not adversely interfere with chemotherapy and pre-clinical studies indicate that it may in fact act synergistically in combination with different chemotherapeutic agents. Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115501/ see also>> https://www.medicalnewstoday.com/articles/272408.php




IVC can augment Radio Therapy


There is new research (early 2019) that shows when IVC is used alongside radiotherapy, for some types of cancer, IVC can enhance the radiosensitivity of tumors using this treatment. https://www.ncbi.nlm.nih.gov/pubmed/?term=PMID%3A+30376411




What are the relevant mechanisms of action of IVC?


A number of plausible anti-cancer mechanisms have been proposed, such as indirect generation of hydrogen peroxide, enzyme cofactor activities (e.g., collagen synthesis, HIF hypoxic response regulation, TET and JHDM epigenetic regulation), as well as antioxidant and anti-inflammatory functions. Different cancers likely respond differently to IVC therapy depending upon their underlying mechanisms. Thus, future work should focus on tailoring IVC regimens to specific cancers or cancer subtypes, e.g., hematological cancers that are driven specifically by TET mutations may respond more readily to IVC therapy. Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115501/




IVC reduces Fatigue, one of the most common issues for patients with cancer


Fatigue is one of the most common and debilitating symptoms reported by cancer patients and can affect QOL more than pain. Several recent studies have indicated that intravenous (IV) vitamin C alleviates a number of cancer- and chemotherapy-related symptoms, such as fatigue, insomnia, loss of appetite, nausea, and pain. Improvements in physical, role, cognitive, emotional, and social functioning, as well as an improvement in overall health, were also observed. The Effect of Intravenous Vitamin C on Cancer- and Chemotherapy-Related Fatigue and Quality of Life https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199254/




IVC helps with Pain, that can be experienced by some patients with cancer.


The prevalence of hypovitaminosis C and vitamin C deficiency is high in various patient groups, such as surgical/trauma, infectious diseases and cancer patients. A number of recent clinical studies have shown that vitamin C administration to patients with chronic regional pain syndrome decreases their symptoms. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391567/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142887/




IVC has been shown to slow the progression of some cancers


Apart from its biochemical functions that are met by healthy nutritional levels, recent pharmacokinetic data indicate that intravenous administration of ascorbate bypasses the tight control of the gut and renal excretion; thus, intravenous administration of ascorbate will produce highly elevated plasma levels; this ascorbate will autoxidize resulting in a high flux of extracellular H2O2. This H2O2 will readily diffuse into cells challenging the intracellular peroxide-removal system, initiating oxidative cascades. These high fluxes of H2O2 appear to have little effect on normal cells but can be detrimental to certain tumor cells. Knowledge and understanding of these mechanisms brings a rationale to the use of high-dose ascorbate to treat disease and thereby is reviving interest in the use of i.v. ascorbate in cancer treatment. Ascorbic acid: Chemistry, biology and the treatment of cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608474/ ______________________________________ Anti-Angiogenesis "Our studies have demonstrated that high concentrations of AA (ascorbic acid - vitamin c) affect the initial phase of cell migration and tube vessel formation and thereby can inhibit angiogenesis" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562367/




IVC has been shown as an excellent Palliative treatment


"Intravenous vitamin C application seems to reduce pain in patients in comparison to other patients who did not receive it. Patient performance status and survival rate were increased using vitamin C." https://www.ncbi.nlm.nih.gov/pubmed/26168394 -------------------------- "Improvements in physical, emotional, cognitive, and social functioning were also observed, as well as an enhancement of overall QOL. With respect to the multidimensional aspects of fatigue, a decrease in physical, emotional, and mental fatigue, resulting in a 50% decrease in total fatigue, was observed following vitamin C administration." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199254/#S4title -------------------------- In terminal cancer patients, the quality of life is as important as cure. Although there is still controversy regarding anticancer effects of vitamin C, t he use of vitamin C is considered a safe and effective therapy to improve the quality of life of terminal cancer patients. https://www.ncbi.nlm.nih.gov/pubmed/17297243/




IVC reduces Inflammation in patients with cancer.


Inflammation plays a key role in tumour development, affecting tumour proliferation, angiogenesis, metastasis, and resistance to therapy. Key features of cancer-related inflammation (CRI) include leukocyte infiltration, cytokine build-up, tissue remodelling, and angiogenesis. The high dose intravenous ascorbic acid (Vitamin C) therapy affects C-reactive protein levels and pro-inflammation cytokines in cancer patients. In our study, we found that modulation of inflammation by IVC correlated with decreases in tumor marker levels. Effect of high-dose intravenous vitamin C on inflammation in cancer patients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480897/ Also see> "..in the last 15 years, the many cofactor functions of ascorbate have come to the fore"
Vitamin C and immune cell function in inflammation and cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195639/




IVC aids healing after surgery


Barrier Integrity and Wound Healing The skin has numerous essential functions, the primary of which is to act as a barrier against external insults, including pathogens. The epidermal layer is highly cellular, comprising primarily keratinocytes, whilst the dermal layer comprises fibroblasts which secrete collagen fibers, the major component of the dermis [ ref]. Skin contains millimolar concentrations of vitamin C, with higher levels found in the epidermis than the dermis. Vitamin C is actively accumulated into the epidermal and dermal cells via the two sodium-dependent vitamin C transporter (SVCT) isoforms 1 and 2, suggesting that the vitamin has crucial functions within the skin. Clues to the role of vitamin C in the skin come from the symptoms of the vitamin C deficiency disease scurvy, which is characterized by bleeding gums, bruising, and impaired wound healing. These symptoms are thought to be a result of the role of vitamin C as a co-factor for the prolyl and lysyl hydroxylase enzymes that stabilize the tertiary structure of collagen. Further research has shown that vitamin C can also increase collagen gene expression in fibroblasts. Full study links in section 2 here >> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/




IVC boosts the Immune System


More than half a century of research has shown Vitamin C to be a crucial player in various aspects of the immune system, particularly immune cell function. Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic and gene regulatory enzymes. Vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system. Vitamin C supports epithelial barrier function against pathogens and promotes the oxidant scavenging activity of the skin, thereby potentially protecting against environmental oxidative stress. Vitamin C accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of reactive oxygen species, and ultimately microbial killing. It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage. The role of vitamin C in lymphocytes is less clear, but it has been shown to enhance differentiation and proliferation of B- and T-cells, likely due to its gene regulating effects. Vitamin C deficiency results in impaired immunity and higher susceptibility to infections. In turn, infections significantly impact on vitamin C levels due to enhanced inflammation and metabolic requirements. Furthermore, supplementation with vitamin C appears to be able to both prevent and treat respiratory and systemic infections. Prophylactic prevention of infection requires dietary vitamin C intakes that provide at least adequate, if not saturating plasma levels (i.e., 100–200 mg/day), which optimize cell and tissue levels. In contrast, treatment of established infections requires significantly higher (gram) doses of the vitamin to compensate for the increased inflammatory response and metabolic demand. Vitamin C and Immune Function https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/ Also see> "..in the last 15 years, the many cofactor functions of ascorbate have come to the fore"
Vitamin C and immune cell function in inflammation and cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195639/




Is IVC a vitamin or a drug?


IVC shifts ascorbate function from a simple anti-scurvy vitamin to a surprisingly beneficial pro-oxidant with powerful pharmaceutical actions. Pharmaceutical IVC doses have shown significant anticancer effects in studies. This well studied effect has been described as the “selective cytotoxicity effect of high dose ascorbate on tumor cells.” Numerous research institutions have replicated this effect over the last several decades. Only recently has research on sepsis brought this effect to the attention of conventional medicine. ----------------------- Recently IVC is also being referred to as Pharmacological Ascorbate Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma. https://www.ncbi.nlm.nih.gov/pubmed/29547353




Why is IV Vitamin C considered to be 'controversial'?


..........under construction.......





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