Sample IV Vitamin C Studies

this page under construction - more will added during Jan '19

Vitamin C is also known as "Ascorbic acid" and L-ascorbic acid, and is a very highly studied element in medical literature.  There are over 53,000 studies on PubMed alone, and more can be found in other medical journals and publications going back to the 1930's. Below are just some sample studies, but many thousands more can be found on PubMed.gov

Intravenous vitamin C in the supportive care of cancer patients: a review and rational approach

" The use of IV C is a safe supportive intervention to decrease inflammation in the patient and to improve symptoms related to antioxidant deficiency, disease processes, and side effects of standard cancer treatments."

Intravenous vitamin C administration improves Quality of Life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany.

" Complementary treatment of breast cancer patients with high-dosage i.v. vitamin C (Pascorbin® 7.5 g) was shown to be a well-tolerated optimization of standard tumour-destructive therapies, mainly reducing Quality of Life related side-effects."

https://www.ncbi.nlm.nih.gov/pubmed/22021693

 

Full study - long version  http://iv.iiarjournals.org/content/25/6/983.long

Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients

" Evidence suggests that IVC may be able to modulate inflammation, which in turn might improve outcomes for cancer patients. IVC may serve as a safe, adjunctive therapy in clinical cancer care."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751545/

Changes of Terminal Cancer Patients' Health-related Quality of Life after High Dose Vitamin C Administration

 

" the use of vitamin C is considered the safe and effective therapy to improve the quality of life in terminal cancer patients."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693571/

 

Therapeutic efficacy of high-dose vitamin C on acute pancreatitis and its potential mechanisms.

 

" the therapeutic efficacy of high dose of vitamin C was much better than that of low dose of vitamin C. Therefore, we conclude that high-dose vitamin C has therapeutic efficacy on acute pancreatitis."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656542/

 

High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy.

" Because of marked pharmacokinetic differences, intravenous, but not oral, ascorbate produces millimolar concentrations both in blood and in tissues, killing cancer cells without harming normal tissues. In the interstitial fluid surrounding tumor cells, millimolar concentrations of ascorbate exert local pro-oxidant effects by mediating hydrogen peroxide (H(2)O(2)) formation, which kills cancer cells. "

https://www.ncbi.nlm.nih.gov/pubmed/24500406

 

 

 

 

 

 

 

Palliative Vitamin C Application in Patients with Radiotherapy-Resistant Bone Metastases: A Retrospective Study.

 

" Intravenous vitamin C application seems to reduce pain in patients in comparison to other patients who did not receive it. Patient performance status and survival rate were increased using vitamin C."

https://www.ncbi.nlm.nih.gov/pubmed/26168394

 

 

 

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

 

" ..administering ascorbic acid in pharmacological dosages to critically ill patients with sepsis is safe and that it may provide adjunctive therapy in the treatment of severe sepsis."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937164/

Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects

" Based on emerging evidence, vitamin C in pharmacologic concentrations appears to be a pro-drug for delivery of hydrogen peroxide to the extravascular space. High dose IV vitamin C appears to have a positive safety profile, favorable pharmacology, evidence for mechanism of action.."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898816/

 

 

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.

" Our results suggest that the early use of intravenous vitamin C, together with corticosteroids and thiamine, are effective in preventing progressive organ dysfunction, including acute kidney injury, and in reducing the mortality of patients with severe sepsis and septic shock"

https://www.ncbi.nlm.nih.gov/pubmed/27940189

 

 

 

 

Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate.

" In addition to the increase in survival times, the administration of large doses of ascorbate seemed to improve the quality of life."

 

https://www.ncbi.nlm.nih.gov/pubmed/6811475?report=abstract

 

Scurvy in patients with cancer

" Scurvy should be considered in patients with cancer because of the high incidence of malnutrition caused by the chemotherapy, cachexia caused by the disease, and other factors that might lead to an unbalanced dietary intake"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1113239/

Effect of Vitamin C Supplementation on C-reactive Protein Levels in Patients Undergoing Hemodialysis: A Randomized, Double Blind, Placebo-Controlled Study

" Our findings demonstrated that there was a reverse relation between supplemental vitamin C and CRP levels, and vitamin C supplementation could modify the levels of CRP in patients on hemodialysis."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968960/

 

Effect of high-dose intravenous vitamin C on inflammation in cancer patients

 

" The high dose intravenous ascorbic acid therapy affects C-reactive protein levels and pro-inflammation cytokines in cancer patients. In our study, we found that modulation of inflammation by IVC correlated with decreases in tumor marker levels."

 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480897/

The Anti-tumor Activity of Vitamin C via the Increase of Fas (CD95) and MHC I Expression on Human Stomach Cancer Cell Line, SNU1

 

" Taken together, vitamin C increases the susceptibility of tumor cells to anti-Fas Abs and the expression of Fas (CD95) and MHC class I on tumor cells."

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202620/

 

Effect of high dose vitamin C on Epstein-Barr viral infection

" The clinical study of ascorbic acid and EBV infection showed the reduction in EBV EA IgG and EBV VCA IgM antibody levels over time during IVC therapy...."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015650/

 

Antioxidants in cancer therapy; their actions and interactions with oncologic therapies.

" Evidence reviewed here demonstrates exogenous antioxidants alone produce beneficial effects in various cancers, and except for a few specific cases, animal and human studies demonstrate no reduction of efficacy of chemotherapy or radiation when given with antioxidants. In fact, considerable data exists showing increased effectiveness of many cancer therapeutic agents, as well as a decrease in adverse effects, when given concurrently with antioxidants."

 

https://www.ncbi.nlm.nih.gov/pubmed/10559547

 

 

 

High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy.

 

" We propose, therefore, a working hypothesis that multiple antioxidant vitamin supplements together with diet and lifestyle modifications may improve the efficacy of standard and experimental cancer therapies."

https://www.ncbi.nlm.nih.gov/pubmed/10067654

 

Anti-angiogenic effect of high doses of Ascorbic Acid  

 

" Our studies have demonstrated that high concentrations of AA affect the initial phase of cell migration and tube vessel formation and thereby can inhibit angiogenesis."

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562367/

 

 

Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications.

 

" When given in combination with standard therapy and in the absence of renal failure, the overall reported adverse events were not greater than therapy-induced complaints. There was no increase in toxicity; yet, the results were promising and decreased levels of the inflammatory marker CRP were shown, as well as an improvement in the efficacy of chemotherapy and thus, an increase in survival times. Moreover, patients reported an improvement in quality of life and increased energy."

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164730/

Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries. 

 

"  With i.v. administration, ascorbate is turned from vitamin to drug, as pharmacologic concentrations are produced that are as much as 100-fold higher than those possible with maximal oral dosing. Pharmacologic ascorbate, by acting as a pro-drug for H2O2 in the extracellular fluid, has potential in treatment of cancer, infectious diseases, and perhaps other conditions in which H2O2 may have efficacy."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065766/

Inflammation in the Vascular Bed.    Importance of Vitamin C

Dr. Albert Szent-Györgyi is recognised as the 'discoverer' of Vitamin C.  He received the 1937 Nobel Prize in Physiology or Medicine, in part for his discovery that hexuronic acid, which he had isolated from adrenal gland, was indeed vitamin C. Dr. Szent-Györgyi stated in a foreword to a book authored by Irwin Stone entitled “The Healing Factor. Vitamin C Against Disease” (Stone, 1972):

“...All the same, I always had the feeling that not enough use was made of it [vitamin C] for supporting human health. The reasons are rather complex. The medical profession itself took a very narrow and very wrong view. Lack of ascorbic acid caused scurvy, so if there was no scurvy there was no lack of ascorbic acid. Nothing could be clearer than this. The only trouble was that scurvy is not a first symptom of a lack but a final collapse, a pre-mortal syndrome and there is a very wide gap between scurvy and full health.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538426/

this page under construction - more will added to this short sample list during 2019

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