Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals

BioMed Research International, peer reviewed Journal - 2016

https://www.hindawi.com/journals/bmri/2016/8274504/

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" Recent research suggests that EDTA chelation may be a well-tolerated and effective treatment method for postmyocardial infarction patients. Toxic metals are pollutants that can represent cardiovascular risk factors and are involved in the development of vascular complications, especially in diabetic patients. Indeed, EDTA chelation therapy can be promoted as treatment for heart disease, particularly in patients with diabetes. Toxic metals also exert an important role in the pathogenesis of ND."

"EDTA chelation therapy has been shown to improve neurologic symptoms in ND patients, and results are further enhanced by the use of antioxidants. EDTA chelation therapy, at the dose of 2 g/week slowly injected IV in adults, does not provoke side effects, can be used for a long period to ameliorate both acute and chronic intoxications, and is able to remove all toxic metals and reduce oxidative stress injury and inflammation in blood vessel walls. EDTA treatment represents an important option in the treatment of ND and CVD associated with metal burden. No interaction is known regarding the drugs commonly used for CVD or ND with EDTA."

Chelation for Lead toxicity is the default treatment at the Mayo Clinic

Mayo Clinic

https://www.mayoclinic.org/diseases-conditions/lead-poisoning/diagnosis-treatment/drc-20354723

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  For more-severe cases, your doctor might recommend:

• Chelation therapy. In this treatment, a medication given by mouth binds with the lead so that it's excreted in urine. Chelation therapy might be recommended for children with a blood level of 45 mcg/dL or greater and adults with high blood levels of lead or symptoms of lead poisoning.

• EDTA chelation therapy. Doctors treat adults with lead levels greater than 45 mcg/dL of blood and children who can't tolerate the drug used in conventional chelation therapy most commonly with a chemical called calcium disodium ethylenediaminetetraacetic acid (EDTA). EDTA is given by injection

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Note:  August 2018 WHO declare "  There is no known level of lead exposure that is considered safe."   click here..

Lead toxicity: a review

PubMed - 2015

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961898/

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The conventional gold standard for treating Lead Toxicity is EDTA Chelation Therapy

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"Lead poisoning is generally treated by using chelating salt disodium calcium edentate, which is the calcium chelate of the disodium salt of ethylene-diamine-tetracetic acid (EDTA). Such chelating agents have a great affinity to the removing agent. The chelating agent for lead has a greater affinity to lead than calcium and so the lead chelate is formed by exchange. This is then excreted in urine, leaving behind harmless calcium."

Cadmium toxicity and treatment: An update  2017

PubMed - 2017

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596182/

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"Patients with cadmium toxicity need gastrointestinal tract irrigation, supportive care, and chemical decontamination traditional-based chelation therapy with appropriate new chelating agents and nanoparticle-based antidotes."

Recommendations for Medical Management of Adult Lead Exposure

PubMed - 2007

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1849937/#b34-ehp0115-000463

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"In our experience, adults with blood lead concentrations ≥ 100 μg/dL almost always warrant chelation"

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Note:  August 2018 WHO declare "  There is no known level of lead exposure that is considered safe."   click here..